PDX MINIMUM INFORMATION STANDARD

The PDX Minimal Information document represents the results of a broad community effort to develop a standard regarding the essential information needed to describe a PDX model. This work was published in the dedicated informatics issue of Cancer Research (Nov. 2017) and is serving as the basis for the PDX Finder’s comprehensive search and attribute filtering options (e.g., tumor histology, molecular variant, drug response). The minimal information standard will be an evolving resource based on community feedback.

Comments about the standards are welcome and can be sent to MGI User Support Be sure to include “PDX MI” as the Subject.

PDX-MI: Minimal Information for Patient-Derived Tumor Xenograft Models

Authors

Terrence F. Meehan^1*, Nathalie Conte^1*, Theodore C. Goldstein², Giorgio Inghirami³, Mark A. Murakami⁴, Sebastian Brabetz^5,6, Zhiping Gu⁷, Jeffrey A. Wiser⁷, Patrick Dunn⁷, Dale A. Begley⁸, Debra M. Krupke⁸, Andrea Bertotti⁹, Alejandra Bruna¹⁰, Matthew Brush¹¹, Annette T. Byrne¹², Carlos Caldas¹⁰, Amanda L. Christie⁴, Dominic Clark¹, Heidi Dowst¹³, Jonathan R. Dry¹⁴, James Doroshow¹⁵, Olivier Duchamp¹⁶, Yvonne A. Evrard¹⁷, Stephane Ferretti¹⁸, Kristopher K. Frese¹⁹, Neal C. Goodwin²⁰, Danielle M. Greenawalt²¹, Melissa A. Haendel¹¹, Els Hermans²², Peter J. Houghton²³, Jos Jonkers²⁴, Kristel Kemper²⁴, Tin O. Khor²⁵, Michael T. Lewis²⁶, KC Kent Lloyd²⁷, Jeremy C. Mason¹, Enzo Medico⁹, Steven B. Neuhauser⁸, Jim M. Olson²⁸, Daniel S. Peeper²⁴, Oscar M. Rueda¹⁰, Je Kyung Seong²⁹, Livio Trusolino⁹, Emilie Vinolo³⁰, Robert J. Wechsler-Reya³¹, David M. Weinstock⁴, Alana Welm³², Saravut J. Weroha³³, Frédéric Amant^24,34, Stefan M Pfister ^5,6,35, Marcel Kool⁵, Helen Parkinson¹, Atul J. Butte², Carol J. Bult⁸

^* = These authors contributed equally to the manuscript

Institutes

¹European Molecular Biology Laboratory-European Bioinformatics Institute, Hinxton, UK. ²Institute for Computational Health Sciences, University of California, San Francisco, USA. ³Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, USA. ⁴Dana-Farber Cancer Institute and Harvard Medical School, Boston, USA. ⁵Division of Pediatric Neuro-oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany. ⁶German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany. ⁷Northrop Grumman Information Systems Health IT, Rockville, USA. ⁸The Jackson Laboratory, Bar Harbor, USA. ⁹Candiolo Cancer Institute IRCCS and Department of Oncology, University of Torino, Torino, Italy. ¹⁰Cancer Research UK Cambridge Institute, Cambridge Cancer Centre, University of Cambridge, United Kingdom. ¹¹Department of Medical Informatics and Clinical Epidemiology and OHSU Library, Oregon Health & Science University, Portland, USA. ¹²Royal College of Surgeons in Ireland, Ireland. ¹³Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, USA. ¹⁴Oncology Innovative Medicines and Early Development, AstraZeneca R&D Boston, Waltham, MA, USA. ¹⁵Center for Cancer Research, National Cancer Institute, USA. ¹⁶Oncodesign Biotechnology, and IMODI consortium, France. ¹⁷Leidos Biomedical Research, Inc, Frederick National Laboratory for Cancer Research, Frederick, USA. ¹⁸Oncology Disease Area, Novartis Institutes for Biomedical Research, Switzerland. ¹⁹Cancer Research UK Manchester Institute, The University of Manchester, United Kingdom. ²⁰Champions Oncology, Baltimore, USA. ²¹ Translational Bioinformatics
Bristol-Myers Squibb, Pennington, New Jersey USA. ²²Katholieke Universiteit Leuven, Leuven, Belgium. ²³Greehey Children’s Cancer Research Institute, University of Texas Health Science Center at San Antonio, San Antonio, USA. ²⁴The Netherlands Cancer Institute, Amsterdam, Netherlands. ²⁵MD Anderson Cancer Center, USA. ²⁶The Lester and Sue Smith Breast Center, Departments of Molecular and Cellular Biology and Radiology, Baylor College of Medicine, USA. ²⁷Department of Surgery, School of Medicine, and Mouse Biology Program, University of California Davis, Davis, USA. ²⁸Fred Hutchinson Cancer Research Center, Seattle Children’s Hospital, USA. ²⁹Research Institute for Veterinary Science and Korea Mouse Phenotyping Center, Seoul , Republic of Korea. ³⁰Seeding Science SAS, Paris, France. ³¹Tumor Initiation and Maintenance Program, NCI-Designated Cancer Center, La Jolla, USA. ³²Huntsman Cancer Institute, University of Utah, Salt Lake City, USA. ³³Department of Oncology, Mayo Clinic College of Medicine, Rochester, USA. ³⁴University of Leuven, Leuven, Belgium. ³⁵Department of Pediatric Oncology, Hematology and Immunology, Heidelberg University Hospital, Heidelberg, Germany.